Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process ct 66 0.0 0.718 0.083 0.17
biological_process el 66 0.059 0.965 0.61 0.251
biological_process ka 66 0.0 0.679 0.081 0.17
biological_process rf 66 0.0 0.718 0.083 0.17
cellular_component ct 67 0.0 0.879 0.124 0.197
cellular_component el 67 0.009 0.997 0.445 0.267
cellular_component ka 67 0.0 0.886 0.128 0.2
cellular_component rf 67 0.0 0.868 0.124 0.197
disease ct 22 0.001 0.841 0.135 0.242
disease el 22 0.005 0.695 0.18 0.221
disease ka 22 0.0 0.851 0.136 0.249
disease rf 22 0.001 0.841 0.134 0.242
interaction ct 69 0.0 0.741 0.035 0.123
interaction el 69 0.0 0.779 0.039 0.135
interaction ka 69 0.0 0.969 0.183 0.291
interaction rf 69 0.0 0.74 0.035 0.122
molecular_function ct 67 0.0 0.994 0.152 0.285
molecular_function el 67 0.048 0.993 0.474 0.301
molecular_function ka 67 0.0 0.97 0.152 0.283
molecular_function rf 67 0.0 0.994 0.151 0.285
pathway ct 29 0.001 0.996 0.071 0.183
pathway el 29 0.001 0.185 0.028 0.048
pathway ka 29 0.001 0.865 0.179 0.274
pathway rf 29 0.001 0.157 0.031 0.044
phenotype ct 23 0.0 0.868 0.193 0.273
phenotype el 23 0.03 0.847 0.484 0.203
phenotype ka 23 0.0 0.967 0.206 0.303
phenotype rf 23 0.0 0.861 0.193 0.272

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 69 0.0 0.876 0.122 0.248
integration_mean_by_presence el 69 0.0 0.862 0.197 0.232
integration_mean_by_presence ka 69 0.0 0.814 0.062 0.167
integration_mean_by_presence rf 69 0.0 0.321 0.025 0.063
mean ct 69 0.0 0.867 0.099 0.231
mean el 69 0.0 0.805 0.111 0.181
mean ka 69 0.0 0.575 0.037 0.102
mean rf 69 0.0 0.327 0.033 0.078

CDF plots of non integrated kernels

CDF plots of integrated kernels